Fragile X-associated Primary Ovarian Failure (FXPOI)
- Article
- 2021-02-28
In 1991 scientists supported by NICHD discovered the gene ( FMR1 ) that causes Fragile X syndrome (FXS) on the X chromosome. FXS is the most common form of hereditary intellectual and developmental disabilities. More recently, researchers have identified two conditions - FXPOI and Fragile X-associated tremor / ataxia syndrome - that are also related to changes in the FMR1 gene, but have features and symptoms that are very different from FXS. Women with FXPOI often experience irregular periods, early infertility and premature menopause. They are also at an increased risk of heart disease and osteoporosis (thinning and weakening of the bones).
Researchers working for and with support across the NIH have made significant strides in understanding FXPOI.
Common names
- Fragile X-associated Primary Ovarian Failure (FXPOI)
Medical or scientific names
- Fragile X-associated primary ovarian insufficiency
- FXPOI (pronounced FAKS-poi )
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